Bile levels of carcino-embryonic antigen in patients with hepatopancreatobiliary disease

Eur J Gastroenterol Hepatol. 1996 Feb;8(2):131-4. doi: 10.1097/00042737-199602000-00007.

Abstract

Objective: To evaluate the value of biliary carcino-embryonic antigen (CEA) in the differential diagnosis of malignant and benign hepatopancreatobiliary disease.

Patients: One hundred patients were prospectively studied. Benign diseases were present in 39% of the patients while 61% had malignant diseases.

Methods: Samples of serum were taken from all patients just before endoscopic retrograde cholangiopancreatography (ERCP) and samples of biliary CEA were obtained during ERCP.

Results: The sensitivity of serum CEA and carbohydrate antigen 19-9 (CA 19-9) in detecting malignancy were 50% and 92%, respectively, while the respective specificities were 95% and 72%. The mean biliary CEA level of the benign group was significantly different from that of the malignant group (35.7 +/- 8.7 ng/ml vs 268 +/- 85.5 ng/ml), but there was considerable overlap between the two groups. With a cut-off level of 20 ng/ml, the sensitivity and specificity were 84% and 64% respectively. The mean bilirubinaemia value was significantly higher in malignant disease than in benign disease (57.4 +/- 13.9 mumol/l vs 235 +/- 19.8 mumol/l). Multidimensional analysis indicated that only bilirubinaemia (P < 109-3)) was independently predictive of malignant disease.

Conclusion: Biliary CEA assessment seems useless in distinguished between benign and malignant causes of cholestasis.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Bile / chemistry*
  • Biliary Tract Diseases / diagnosis*
  • Biliary Tract Neoplasms / diagnosis
  • Biomarkers, Tumor / analysis*
  • CA-19-9 Antigen / blood
  • Carcinoembryonic Antigen / analysis*
  • Carcinoembryonic Antigen / blood
  • Cholestasis / diagnosis
  • Diagnosis, Differential
  • Female
  • Humans
  • Liver Diseases / diagnosis*
  • Liver Neoplasms / diagnosis
  • Male
  • Middle Aged
  • Pancreatic Diseases / diagnosis*
  • Pancreatic Neoplasms / diagnosis
  • Prospective Studies
  • Sensitivity and Specificity

Substances

  • Biomarkers, Tumor
  • CA-19-9 Antigen
  • Carcinoembryonic Antigen