Oxidative stress in rat liver and lung induced by furanoterpenoids isolated from Fusarium solani infected sweet potatoes

Indian J Exp Biol. 1996 Jan;34(1):57-60.

Abstract

A crude extract containing some toxic furanoterpenoids was isolated from F. solani infected sweet potatoes. Chronic administration of the crude extract to male albino rats at a dosage of 1 mg/kg body weight/day for 21 days brought about a sharp increase in the thiobarbituric acid reactive substances and a depression of glutathione levels in the lung and liver homogenates. The antioxidant defense system was affected as evident from a significant fall in the activities of the enzymes, superoxide dismutase, catalase, glutathione peroxidase, glucose-6-phosphate dehydrogenase and glutathione-S-transferase. Such an alteration could be the reason for the lung and liver damage caused by these toxic furanoterpenoids.

MeSH terms

  • Animals
  • Furans / isolation & purification*
  • Fusarium / metabolism
  • Fusarium / physiology*
  • Liver / drug effects*
  • Liver / metabolism
  • Lung / drug effects*
  • Lung / metabolism
  • Male
  • Mycoses / metabolism*
  • Oxidative Stress / drug effects*
  • Rats
  • Rats, Wistar
  • Terpenes / isolation & purification*
  • Vegetables / metabolism
  • Vegetables / microbiology*

Substances

  • Furans
  • Terpenes