PCR detection of cytomegalovirus DNA in serum as a diagnostic test for congenital cytomegalovirus infection

J Clin Microbiol. 1995 Dec;33(12):3317-8. doi: 10.1128/jcm.33.12.3317-3318.1995.

Abstract

PCR detected cytomegalovirus (CMV) DNA in the serum of 18 of 18 infants with symptomatic congenital CMV infection, 1 of 2 infants with asymptomatic congenital CMV infection, and 0 of 32 controls. Serum CMV PCR provided a rapid, sensitive, and specific method for diagnosis of congenital CMV infection in infants who were symptomatic at birth.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies, Viral / blood
  • Cytomegalovirus / genetics*
  • Cytomegalovirus / immunology
  • Cytomegalovirus / isolation & purification*
  • Cytomegalovirus Infections / congenital*
  • Cytomegalovirus Infections / diagnosis*
  • Cytomegalovirus Infections / virology
  • DNA, Viral / blood*
  • DNA, Viral / genetics*
  • Female
  • Humans
  • Immunoglobulin M / blood
  • Infant, Newborn
  • Male
  • Polymerase Chain Reaction / methods*
  • Polymerase Chain Reaction / statistics & numerical data
  • Sensitivity and Specificity
  • Urine / virology

Substances

  • Antibodies, Viral
  • DNA, Viral
  • Immunoglobulin M