Abstract
PCR detected cytomegalovirus (CMV) DNA in the serum of 18 of 18 infants with symptomatic congenital CMV infection, 1 of 2 infants with asymptomatic congenital CMV infection, and 0 of 32 controls. Serum CMV PCR provided a rapid, sensitive, and specific method for diagnosis of congenital CMV infection in infants who were symptomatic at birth.
Publication types
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Clinical Trial
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Controlled Clinical Trial
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antibodies, Viral / blood
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Cytomegalovirus / genetics*
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Cytomegalovirus / immunology
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Cytomegalovirus / isolation & purification*
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Cytomegalovirus Infections / congenital*
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Cytomegalovirus Infections / diagnosis*
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Cytomegalovirus Infections / virology
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DNA, Viral / blood*
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DNA, Viral / genetics*
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Female
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Humans
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Immunoglobulin M / blood
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Infant, Newborn
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Male
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Polymerase Chain Reaction / methods*
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Polymerase Chain Reaction / statistics & numerical data
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Sensitivity and Specificity
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Urine / virology
Substances
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Antibodies, Viral
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DNA, Viral
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Immunoglobulin M