Abstract
Measles virus (MV) infection of U937 cell or peripheral blood leukocyte cultures was shown to induce changes in the expression of leukocyte function antigen 1 (LFA-1) and cause marked aggregation of these cells. Addition of selected monoclonal antibodies specific for LFA-1 epitopes that did not neutralize MV in standard neutralization assays were found to block both virus-induced leukocyte aggregation and virus dissemination. These data suggest that MV modulation of LFA-1 expression on leukocytes may be an important step in MV pathogenesis.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antibodies, Monoclonal / pharmacology
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Antigens, CD / biosynthesis*
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CD18 Antigens
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Cell Aggregation / drug effects
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Culture Media / pharmacology
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Flow Cytometry
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Gene Expression Regulation
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Humans
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Integrins / drug effects
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Leukocytes, Mononuclear / microbiology*
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Lymphocyte Function-Associated Antigen-1 / biosynthesis*
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Measles / etiology*
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Measles virus / physiology*
Substances
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Antibodies, Monoclonal
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Antigens, CD
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CD18 Antigens
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Culture Media
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Integrins
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Lymphocyte Function-Associated Antigen-1