Roentgenoendoscopic interventions combining diagnostic and therapeutic procedures were carried out in 320 patients with various pancreatobiliary diseases. Different combinations of therapeutic roentgenoendovascular interventions on the biliferous system are shown, which were used in 102 patients with clolelithiasis. These interventions were found a highly effective method for preoperative treatment and therapy of patients with cholelithiasis. Roentgenoendovascular interventions in cholelithiasis are conductive to optimization of surgical treatment.