Regrowing the heart, one TREE at a time

Jeffrey D Steimle; James F Martin

doi:10.1016/j.stem.2022.12.004

Regrowing the heart, one TREE at a time

Cell Stem Cell. 2023 Jan 5;30(1):1-2. doi: 10.1016/j.stem.2022.12.004.

Authors

Jeffrey D Steimle¹, James F Martin²

Affiliations

¹ Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.
² Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA; Cardiomyocyte Renewal Laboratory, Texas Heart Institute, Houston, TX 77030, USA; Center for Organ Repair and Renewal, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: jfmartin@bcm.edu.

PMID: 36608673
DOI: 10.1016/j.stem.2022.12.004

Abstract

While many animals can completely repair injured tissues, the mammalian heart possesses limited regenerative capabilities. Yan and Cigliola et al. show that AAV-mediated, zebrafish-derived tissue regeneration enhancer elements (TREEs) can direct pro-regenerative gene expression in injured cardiac tissue of mice and pigs that turn off following repair.

Publication types

Comment

MeSH terms

Animals
Cell Proliferation
Heart*
Mammals
Myocytes, Cardiac
Swine
Wound Healing / genetics
Zebrafish*

Abstract

Publication types

MeSH terms

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