Current Trends in Liver Transplantation for Alcoholic Hepatitis

Clin Liver Dis. 2021 Aug;25(3):625-634. doi: 10.1016/j.cld.2021.04.002. Epub 2021 May 29.

Abstract

Liver transplantation (LT) for alcohol-related or alcoholic hepatitis (AH) remains a controversial treatment option. However, recent studies have shown promising outcomes for LT in a subgroup of patients with AH. Considering these emerging data, LT as definitive therapy for severe AH refractory to medical management is gaining recognition. However, concerns of alcohol recidivism pose a significant barrier to perform LT for this indication. Predictive models can be utilized to develop a selection criterion to identify suitable candidates for LT. Hence, carefully selected patients with severe AH and low risk of alcohol relapse can be considered for LT.

Keywords: Alcohol relapse; Alcohol-related liver disease; Alcoholic Hepatitis; Liver transplantation.

Publication types

  • Review

MeSH terms

  • Alcohol Abstinence
  • Hepatitis, Alcoholic* / surgery
  • Humans
  • Liver Transplantation*
  • Recurrence