Peripheral Nervous System Manifestations Associated with COVID-19

Curr Neurol Neurosci Rep. 2021 Feb 14;21(3):9. doi: 10.1007/s11910-021-01102-5.

Abstract

Purpose of review: The present review discusses the peripheral nervous system (PNS) manifestations associated with coronavirus disease 2019 (COVID-19).

Recent findings: Nerve pain and skeletal muscle injury, Guillain-Barré syndrome, cranial polyneuritis, neuromuscular junction disorders, neuro-ophthalmological disorders, neurosensory hearing loss, and dysautonomia have been reported as PNS manifestations in patients with COVID-19. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19. COVID-19 has shown syndromic complexity. Not only does SARS-CoV-2 affect the central nervous system but also it involves the PNS. The PNS involvement may be due to dysregulation of the immune system attributable to COVID-19. Here we review the broad spectrum of PNS involvement of COVID-19.

Keywords: COVID-19; Peripheral nervous system manifestations; SARS-CoV-2.

Publication types

  • Review

MeSH terms

  • COVID-19*
  • Central Nervous System
  • Guillain-Barre Syndrome*
  • Humans
  • Nervous System Diseases*
  • Peripheral Nervous System
  • SARS-CoV-2