Coumarin necrosis--a review of the literature

Surgery. 1988 Mar;103(3):271-7.

Abstract

Skin and soft tissue necrosis is a rare complication of anticoagulation therapy. Two patients who exhibited the spectrum of this disorder are described. The clinical features, etiology, pathophysiology, and treatment of coumarin skin necrosis are outlined, and the English-language literature is reviewed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged
  • Coumarins / adverse effects*
  • Ecchymosis / chemically induced
  • Female
  • Hemorrhage / chemically induced
  • Humans
  • Male
  • Middle Aged
  • Necrosis / chemically induced*
  • Purpura / chemically induced
  • Thrombophlebitis / drug therapy
  • Warfarin / adverse effects
  • Warfarin / therapeutic use

Substances

  • Coumarins
  • Warfarin