Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group

Emily L Dennis; Karen Caeyenberghs; Robert F Asarnow; Talin Babikian; Brenda Bartnik-Olson; Erin D Bigler; Anthony Figaji; Christopher C Giza; Naomi J Goodrich-Hunsaker; Cooper B Hodges; Kristen R Hoskinson; Marsh Königs; Harvey S Levin; Hannah M Lindsey; Abigail Livny; Jeffrey E Max; Tricia L Merkley; Mary R Newsome; Alexander Olsen; Nicholas P Ryan; Matthew S Spruiell; Stacy J Suskauer; Sophia I Thomopoulos; Ashley L Ware; Christopher G Watson; Anne L Wheeler; Keith Owen Yeates; Brandon A Zielinski; Paul M Thompson; David F Tate; Elisabeth A Wilde

doi:10.1007/s11682-020-00363-x

Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group

Brain Imaging Behav. 2021 Apr;15(2):555-575. doi: 10.1007/s11682-020-00363-x.

Authors

Emily L Dennis^{1

2

3}, Karen Caeyenberghs⁴, Robert F Asarnow^{5

6

7}, Talin Babikian^{5

8}, Brenda Bartnik-Olson⁹, Erin D Bigler^{10

11

12}, Anthony Figaji^{13

14}, Christopher C Giza^{8

15}, Naomi J Goodrich-Hunsaker^{10

11

16}, Cooper B Hodges^{10

11

16}, Kristen R Hoskinson^{17

18}, Marsh Königs¹⁹, Harvey S Levin^{20

21}, Hannah M Lindsey^{10

11

16}, Abigail Livny^{22

23}, Jeffrey E Max^{24

25}, Tricia L Merkley^{10

11

12}, Mary R Newsome^{20

21}, Alexander Olsen^{26

27}, Nicholas P Ryan^{4

28

29}, Matthew S Spruiell²⁰, Stacy J Suskauer^{30

31}, Sophia I Thomopoulos³², Ashley L Ware³³, Christopher G Watson³⁴, Anne L Wheeler^{35

36}, Keith Owen Yeates^{33

37

38}, Brandon A Zielinski^{10

39}, Paul M Thompson^{32

40}, David F Tate^{10

11

16

41}, Elisabeth A Wilde^{10

16

20}

Affiliations

¹ TBI and Concussion Center, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA. emily.dennis@hsc.utah.edu.
² Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, Los Angeles, CA, USA. emily.dennis@hsc.utah.edu.
³ Psychiatry Neuroimaging Laboratory, Brigham & Women's Hospital, Boston, MA, USA. emily.dennis@hsc.utah.edu.
⁴ Cognitive Neuroscience Unit, School of Psychology, Deakin University, Geelong, Australia.
⁵ Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA.
⁶ Brain Research Institute, UCLA, Los Angeles, CA, USA.
⁷ Department of Psychology, UCLA, Los Angeles, CA, USA.
⁸ UCLA Steve Tisch BrainSPORT Program, Los Angeles, CA, USA.
⁹ Department of Radiology, Loma Linda University Medical Center, Loma Linda, CA, USA.
¹⁰ TBI and Concussion Center, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
¹¹ Department of Psychology, Brigham Young University, Provo, UT, USA.
¹² Neuroscience Center, Brigham Young University, Provo, UT, USA.
¹³ Division of Neurosurgery, University of Cape Town, Cape Town, South Africa.
¹⁴ Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
¹⁵ Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
¹⁶ George E. Wahlen Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, UT, USA.
¹⁷ Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
¹⁸ Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA.
¹⁹ Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Emma Neuroscience Group, Amsterdam, The Netherlands.
²⁰ H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
²¹ Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.
²² Department of Diagnostic Imaging, Sheba Medical Center, Ramat Gan, Tel-Hashomer, Israel.
²³ Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Tel-Hashomer, Israel.
²⁴ Department of Psychiatry, University of California, La Jolla, San Diego, CA, USA.
²⁵ Department of Psychiatry, Rady Children's Hospital, San Diego, CA, USA.
²⁶ Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway.
²⁷ Department of Physical Medicine and Rehabilitation, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
²⁸ Department of Paediatrics, The University of Melbourne, Melbourne, Australia.
²⁹ Department of Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Australia.
³⁰ Kennedy Krieger Institute, Baltimore, MD, USA.
³¹ Departments of Physical Medicine & Rehabilitation and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
³² Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, Los Angeles, CA, USA.
³³ Department of Psychology, University of Calgary, Calgary, Alberta, Canada.
³⁴ Department of Pediatrics, Children's Learning Institute, University of Texas Health Science Center at Houston, Houston, TX, USA.
³⁵ Hospital for Sick Children, Neuroscience and Mental Health Program, Toronto, Canada.
³⁶ Physiology Department, University of Toronto, Toronto, Canada.
³⁷ Alberta Children's Hospital Research Institute and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
³⁸ Departments of Pediatrics and Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
³⁹ Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.
⁴⁰ Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology, USC, Los Angeles, CA, USA.
⁴¹ Missouri Institute of Mental Health and University of Missouri, St Louis, MO, USA.

Abstract

Traumatic brain injury (TBI) is a major cause of death and disability in children in both developed and developing nations. Children and adolescents suffer from TBI at a higher rate than the general population, and specific developmental issues require a unique context since findings from adult research do not necessarily directly translate to children. Findings in pediatric cohorts tend to lag behind those in adult samples. This may be due, in part, both to the smaller number of investigators engaged in research with this population and may also be related to changes in safety laws and clinical practice that have altered length of hospital stays, treatment, and access to this population. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Pediatric Moderate/Severe TBI (msTBI) group aims to advance research in this area through global collaborative meta-analysis of neuroimaging data. In this paper, we discuss important challenges in pediatric TBI research and opportunities that we believe the ENIGMA Pediatric msTBI group can provide to address them. With the paucity of research studies examining neuroimaging biomarkers in pediatric patients with TBI and the challenges of recruiting large numbers of participants, collaborating to improve statistical power and to address technical challenges like lesions will significantly advance the field. We conclude with recommendations for future research in this field of study.

Keywords: ENIGMA; Moderate-severe TBI; Neuroimaging; Pediatric; traumatic brain injury (TBI).

Publication types

Meta-Analysis

MeSH terms

Adolescent
Adult
Biomarkers
Brain Injuries, Traumatic* / diagnostic imaging
Child
Humans
Magnetic Resonance Imaging*
Neuroimaging

Substances

Biomarkers

Abstract

Publication types

MeSH terms

Substances

Grants and funding