Same structure, different mechanisms?

Francis TF Tsai; Christopher P Hill

doi:10.7554/eLife.56501

Same structure, different mechanisms?

Elife. 2020 Apr 23:9:e56501. doi: 10.7554/eLife.56501.

Authors

Francis TF Tsai¹, Christopher P Hill²

Affiliations

¹ Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, United States.
² Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.

Abstract

Two interpretations of similar structures for the same molecular machine illustrate the limits of inferring biochemical mechanism from protein structure.

Keywords: AAA+ protease; E. coli; molecular biophysics; neisseria meningitidis; protein translocation; protein unfolding; structural biology.

Same structure, different mechanisms?

Authors

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Abstract

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