Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders

Affiliations

• ¹ Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, 98195, USA.
• ² Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, 410078, Changsha, Hunan, China.
• ³ Laboratory of Molecular Genetics of Neurodevelopment, Department of Women's and Children's Health, University of Padua, Via Giustiniani 3, 35128, Padua, Italy.
• ⁴ Fondazione Istituto di Ricerca Pediatrica Città della Speranza, Corso Stati Uniti 4, 35129, Padua, Italy.
• ⁵ Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
• ⁶ Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, 77030, USA.
• ⁷ UCSF Department of Anatomy, University of California, San Francisco, San Francisco, CA, 94143, USA.
• ⁸ UCSF Department of Psychiatry, University of California, San Francisco, San Francisco, CA, 94143, USA.
• ⁹ UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, 94158, USA.
• ¹⁰ Department of Human Genetics, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.
• ¹¹ Department of Clinical Genetics, Maastricht University Medical Center, 6202 AZ, Maastricht, The Netherlands.
• ¹² Normandie Univ, UNICAEN, CHU de Caen Normandie, Department of Genetics, EA7450 BioTARGen, 14000, Caen, France.
• ¹³ Greenwood Genetic Center, Greenwood, SC, 29646, USA.
• ¹⁴ Oasi Research Institute-IRCCS, 94108, Troina, Italy.
• ¹⁵ Département de génétique, Hôpital Pitié-Salpêtrière, Assistance Publique - Hôpitaux de Paris, 75013, Paris, France.
• ¹⁶ APHP, Centre de référence des malformations et maladies congénitales du cervelet Département de génétique et embryologie médicale, GRCn°19, pathologies Congénitales du Cervelet-LeucoDystrophies, AP-HP, Hôpital Armand Trousseau, F-75012, Paris, France.
• ¹⁷ Department of Pediatrics, The First People's Hospital of Yunnan Province, 650032, Kunming, Yunnan, China.
• ¹⁸ Medical Faculty, Kunming University of Science and Technology, 650032, Kunming, Yunnan, China.
• ¹⁹ Section of Medical Genomics, Medical Investigation of Neurodevelopmental Disorders Institute, University of California, Davis, Sacramento, CA, 95817, USA.
• ²⁰ Division of Clinical and Metabolic Genetics, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
• ²¹ GeneDx, Gaithersburg, MD, 20877, USA.
• ²² Institute of Human Genetics, University of Leipzig Medical Center, Leipzig, Germany.
• ²³ Department of Pediatrics, Division of Genetic Medicine, University of Washington, Seattle, WA, 98195, USA.
• ²⁴ Departments of Medicine and Paediatrics, The University of Melbourne, Austin Health and Royal Children's Hospital, Melbourne, VIC, 3084, Australia.
• ²⁵ Department of Neurosciences, Queensland Children's Hospital, Brisbane, QLD, 4101, Australia.
• ²⁶ School of Medicine and the Robinson Research Institute, The University of Adelaide at the Women's and Children's Hospital, Adelaide, SA, 5006, Australia.
• ²⁷ Emma Children's Hospital AUMC, 1105 AZ, Amsterdam, The Netherlands.
• ²⁸ North West Thames Genetics Service NHS, London, UK.
• ²⁹ Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Clinical Genetics, Amsterdam, Netherlands.
• ³⁰ Department of Clinical Genetics, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
• ³¹ Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University Hospital of Padua, 35128, Padua, Italy.
• ³² Department of Psychiatry, University of Washington, Seattle, WA, 98195, USA.
• ³³ Program in Developmental Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
• ³⁴ Department of Neuroscience, Baylor College of Medicine, Houston, TX, 77030, USA.
• ³⁵ Hunan Key Laboratory of Animal Models for Human Diseases, 410078, Changsha, Hunan, China.
• ³⁶ Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX, 77030, USA.
• ³⁷ Laboratory of Molecular Genetics of Neurodevelopment, Department of Women's and Children's Health, University of Padua, Via Giustiniani 3, 35128, Padua, Italy. alessandra.murgia@unipd.it.
• ³⁸ Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, 98195, USA. eee@gs.washington.edu.
• ³⁹ Howard Hughes Medical Institute, University of Washington, Seattle, WA, 98195, USA. eee@gs.washington.edu.