Genetic Polymorphism in Cytokines and Costimulatory Molecules in Stem Cell and Solid Organ Transplantation

Peter T Jindra; Matthew F Cusick

doi:10.1016/j.cll.2018.10.002

Genetic Polymorphism in Cytokines and Costimulatory Molecules in Stem Cell and Solid Organ Transplantation

Clin Lab Med. 2019 Mar;39(1):107-123. doi: 10.1016/j.cll.2018.10.002. Epub 2018 Dec 24.

Authors

Peter T Jindra¹, Matthew F Cusick²

Affiliations

¹ Department of Surgery, BCM Immune Evaluation Laboratory, One Baylor Plaza, MS: BCM504, Houston, TX 77030, USA. Electronic address: Peter.Jindra@bcm.edu.
² Department of Surgery, BCM Immune Evaluation Laboratory, One Baylor Plaza, MS: BCM504, Houston, TX 77030, USA.

PMID: 30709500
DOI: 10.1016/j.cll.2018.10.002

Abstract

There is growing evidence supporting the genetic variability outside of HLA system that is contributing to the variation in transplant outcomes. Determining novel predictors could help to identify patients at risk and tailor their immunosuppressive regimens. This article discusses the various single nucleotide polymorphisms in costimulatory molecules and cytokines that have been evaluated for their effect on transplantation. An overview of how gene polymorphism studies are conducted and factors to consider in the experimental design to ensure meaningful data can be concluded are discussed.

Keywords: Co-stimulation; Cytokines; Immune response; Rejection; Single nucleotide polymorphisms; Transplantation; Validation.

Publication types

Review

MeSH terms

B7 Antigens / genetics*
B7 Antigens / metabolism
B7 Antigens / physiology
Cytokines / genetics*
Genome-Wide Association Study
Graft Rejection / immunology*
Humans
Polymorphism, Single Nucleotide*
Receptors, Tumor Necrosis Factor / genetics
T-Lymphocytes / immunology
T-Lymphocytes / physiology
Transplantation*
Treatment Outcome
Tumor Necrosis Factor-alpha / genetics

Substances

B7 Antigens
Cytokines
Receptors, Tumor Necrosis Factor
Tumor Necrosis Factor-alpha