Bone Marrow-Derived and Adipose-Derived Mesenchymal Stem Cell Therapy in Primary Knee Osteoarthritis: A Narrative Review

Prathap Jayaram; Uzoh Ikpeama; Joshua B Rothenberg; Gerard A Malanga

doi:10.1016/j.pmrj.2018.06.019

Bone Marrow-Derived and Adipose-Derived Mesenchymal Stem Cell Therapy in Primary Knee Osteoarthritis: A Narrative Review

PM R. 2019 Feb;11(2):177-191. doi: 10.1016/j.pmrj.2018.06.019. Epub 2019 Jan 16.

Authors

Prathap Jayaram¹, Uzoh Ikpeama², Joshua B Rothenberg³, Gerard A Malanga⁴

Affiliations

¹ H. Ben Taub Dept of Physical Medicine & Rehabilitation, Orthopedic Surgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030.
² H. Ben Taub Dept of Physical Medicine & Rehabilitation, Baylor College of Medicine, Houston, TX.
³ Departments of Regenerative Medicine and Orthopedic Biologics, BocaCare Orthopedics, Boca Raton Regional Hospital, Boca Raton, FL.
⁴ Department of Physical Medicine and Rehabilitation, Rutgers School of Biomedical and Health Sciences, Newark, NJ; Rutgers University and New Jersey Regenerative Medicine Institute, Cedar Knolls, NJ.

PMID: 30010050
DOI: 10.1016/j.pmrj.2018.06.019

Abstract

Regenerative medicine in the context of musculoskeletal injury is a broad term that offers potential therapeutic solutions to restore or repair damaged tissue. The current focus in recent literature and clinical practice has been on cell based therapy. In particular, much attention has been centered on autologous bone marrow concentrate and adipose-derived mesenchymal stem cells (MSCs) for cartilage and tendon disorders. This article provides an overview of MSC-derived therapy and offers a comprehensive review of adipose- and bone marrow-derived MSC therapy in primary knee osteoarthritis. LEVEL OF EVIDENCE: IV.

Publication types

Review

MeSH terms

Adipose Tissue / cytology*
Bone Marrow Cells / cytology*
Bone Marrow Transplantation / methods*
Humans
Mesenchymal Stem Cell Transplantation / methods*
Osteoarthritis, Knee / therapy*
Regenerative Medicine / methods*