Hematopoiesis and the bacterial microbiome

Blood. 2018 Aug 9;132(6):559-564. doi: 10.1182/blood-2018-02-832519. Epub 2018 May 31.

Abstract

Recent studies have revealed that the intestinal bacterial microbiome plays an important role in the regulation of hematopoiesis. A correlation between adverse hematologic effects and imbalance of the intestinal microbiome, or dysbiosis, is evident in several human conditions, such as inflammatory bowel disease, obesity, and, critically, in the setting of antibiotic exposure. Here we review the effects of gut dysbiosis on the hematological compartment and our current understanding of the mechanisms through which changes in the bacterial microbiome affect hematopoiesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / pharmacology
  • Bone Marrow / physiology
  • Dysbiosis / complications*
  • Dysbiosis / microbiology
  • Dysbiosis / physiopathology
  • Gastrointestinal Microbiome* / drug effects
  • Graft Survival
  • Hematopoiesis* / genetics
  • Hematopoiesis* / physiology
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Inflammatory Bowel Diseases / complications
  • Inflammatory Bowel Diseases / microbiology
  • Mice
  • Models, Immunological
  • Myeloid Differentiation Factor 88 / physiology
  • Neutropenia / chemically induced
  • Nod1 Signaling Adaptor Protein / physiology
  • Nutrition Disorders / complications
  • Nutrition Disorders / microbiology
  • Signal Transduction
  • Specific Pathogen-Free Organisms
  • Toll-Like Receptors / physiology

Substances

  • Anti-Bacterial Agents
  • Myeloid Differentiation Factor 88
  • Nod1 Signaling Adaptor Protein
  • Toll-Like Receptors