Inhibition of human lymphocyte cyclic nucleotide phosphodiesterases by the chlorinated adenosine analog DTA-35

M Y Hurwitz; R L Hurwitz; R D Edstrom

doi:10.3109/14756368709020124

Inhibition of human lymphocyte cyclic nucleotide phosphodiesterases by the chlorinated adenosine analog DTA-35

J Enzyme Inhib. 1987;1(4):267-74. doi: 10.3109/14756368709020124.

Authors

M Y Hurwitz¹, R L Hurwitz, R D Edstrom

Affiliation

¹ Department of Biochemistry, University of Minnesota, Minneapolis 55455.

PMID: 2854846
DOI: 10.3109/14756368709020124

Abstract

Human (E+)-T-lymphocytes have multiple cyclic nucleotide phosphodiesterase activities, some of which are markedly inhibited by the chlorinated adenosine derivative 9-(3',5'-dichloro-2',3',5'-trideoxy-beta-D-threo-pentofuranosyl)adenine (DTA-35).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
3',5'-Cyclic-GMP Phosphodiesterases / antagonists & inhibitors*
Deoxyadenosines / analogs & derivatives*
Deoxyadenosines / pharmacology
Humans
Kinetics
Lymphocytes / enzymology*
Lymphocytes / immunology

Substances

Deoxyadenosines
DTA 35
3',5'-Cyclic-AMP Phosphodiesterases
3',5'-Cyclic-GMP Phosphodiesterases