1 1 CS Mott Center for Human Growth and Development, Department of Ob/Gyn, Reproductive Endocrinology and Infertility, 2 Department of Physiology, 3 Department of Pediatrics and Children's Hospital of Michigan, 4 Institutes for Environmental Health Science, Wayne State University School of Medicine, Detroit, MI 48201, USA ; 5 Department of Biology, University of Windsor, Windsor, ON N9B 3P4, Canada.