Mammary Ductal Environment Is Necessary for Faithful Maintenance of Estrogen Signaling in ER⁺ Breast Cancer

Svasti Haricharan; Jonathan Lei; Matthew Ellis

doi:10.1016/j.ccell.2016.02.017

Mammary Ductal Environment Is Necessary for Faithful Maintenance of Estrogen Signaling in ER⁺ Breast Cancer

Cancer Cell. 2016 Mar 14;29(3):249-250. doi: 10.1016/j.ccell.2016.02.017.

Authors

Svasti Haricharan¹, Jonathan Lei², Matthew Ellis³

Affiliations

¹ Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
² Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
³ Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: matthew.ellis@bcm.edu.

Abstract

In this issue of Cancer Cell, Sflomos et al. (2016) describe a robust preclinical animal model of ER⁺ breast cancer. The authors identify the critical role of the breast microenvironment in determining hormone response of ER⁺ breast cancer cells and in driving the luminal phenotype of breast cancer.

Publication types

Comment

MeSH terms

Animals
Breast Neoplasms / genetics*
Breast Neoplasms / pathology*
Estrogen Receptor alpha / genetics*
Female
Humans
Mammary Glands, Human / pathology*
Tumor Microenvironment / genetics*

Substances

Estrogen Receptor alpha

Grants and funding

T32 GM088129/GM/NIGMS NIH HHS/United States