Abstract
A case of therapy-related myelodysplasia followed by acute nonlymphocytic leukemia in a 5-year-old child successfully treated for diffuse Langerhans cell histiocytosis is described. A syndrome of severe cell-mediated immune deficiency and persistent Epstein-Barr virus (EBV) infection coincided with the evolution of myelodysplasia. Specific abnormalities of chromosomes number 7 and 3 were associated with the onset of myelodysplasia and acute nonlymphocytic leukemia and are believed to be linked to the patient's immune dysfunction and compromised ability to contain viral infection.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Chlorambucil / adverse effects*
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Chlorambucil / therapeutic use
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Chromosome Deletion*
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Chromosomes, Human, Pair 3 / ultrastructure*
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Chromosomes, Human, Pair 7 / ultrastructure*
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Female
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Herpesviridae Infections / etiology
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Herpesvirus 4, Human
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Histiocytosis, Langerhans-Cell / complications
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Histiocytosis, Langerhans-Cell / drug therapy*
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Humans
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Immunologic Deficiency Syndromes / complications*
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Immunologic Deficiency Syndromes / genetics
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Infant
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Leukemia, Myeloid, Acute / chemically induced*
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Leukemia, Myeloid, Acute / complications
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Leukemia, Myeloid, Acute / genetics
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Myelodysplastic Syndromes / chemically induced*
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Myelodysplastic Syndromes / complications
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Myelodysplastic Syndromes / genetics
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Skin Diseases / complications
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Skin Diseases / drug therapy*