Effect of desiccating stress on mouse meibomian gland function

Ocul Surf. 2014 Jan;12(1):59-68. doi: 10.1016/j.jtos.2013.08.002. Epub 2013 Oct 18.

Abstract

Purpose: Mice exposed to standardized desiccating environmental stress to induce dry eye-like symptoms have been used as a model to study the underlying mechanisms of evaporative dry eye. While studies have shown marked inflammatory and immune changes, the effect of such stress on meibomian gland function remains largely unknown. We sought to evaluate the effects of desiccating stress on meibocyte proliferation and meibum quality.

Methods: Ten mice were treated with scopolamine and subjected to a drafty low humidity environment (30-35%). Five and ten days after treatment, eyelids were harvested and cryosections stained with Ki67 antibody to identify cycling cells. Sections were also imaged using stimulated Raman scattering (SRS) microscopy to characterize the gland compositional changes by detecting the vibrational signatures of methylene (lipid) and amide-I (protein).

Results: Desiccating stress caused a 3-fold increase in basal acinar cell proliferation from 18.3 ± 11.1% in untreated mice to 64.4 ± 19.9% and 66.6 ± 13.4% after 5 and 10 days exposure, respectively (P < .001). In addition, SRS analysis showed a wider variation in the protein-to-lipid ratio throughout the gland, suggesting alterations in meibocyte differentiation and lipid synthesis.

Conclusions: These data are consistent with a model that a desiccating environment may have a direct effect on meibomian gland function, leading to a significant increase in basal acinar cell proliferation, abnormal meibocyte differentiation, and altered lipid production.

Keywords: evaporative dry eye; meibomian gland; nonlinear optical microscopy; stimulated Raman scattering.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Proliferation
  • Cholinergic Antagonists / pharmacology
  • Desiccation / methods*
  • Disease Models, Animal
  • Dry Eye Syndromes* / chemically induced
  • Dry Eye Syndromes* / pathology
  • Dry Eye Syndromes* / physiopathology
  • Eye Proteins / metabolism
  • Female
  • Humidity
  • Lipid Metabolism
  • Meibomian Glands / pathology*
  • Meibomian Glands / physiopathology*
  • Mice
  • Mice, Inbred C57BL
  • Scopolamine / pharmacology
  • Spectrum Analysis, Raman
  • Stress, Physiological

Substances

  • Cholinergic Antagonists
  • Eye Proteins
  • Scopolamine