Implementing the Jadelle implant for women living with HIV in a resource-limited setting: concerns for drug interactions leading to unintended pregnancies

AIDS. 2014 Mar 13;28(5):791-3. doi: 10.1097/QAD.0000000000000177.

Abstract

An analysis of 570 HIV-infected women in Swaziland using the Jadelle implant showed that age, condom use, the provider who placed the implant, and CD4 cell count had no effect on unintentional pregnancy rates. Antiretroviral regimen at the time of pregnancy, however, correlated with pregnancy outcomes (P < 0.001). None of the women on nevirapine or lopinavir/ritonavir-based regimens (n = 208 and 13, respectively) became pregnant, whereas 15 women on efavirenz (n = 121; 12.4%) became pregnant.

MeSH terms

  • Adolescent
  • Adult
  • Alkynes
  • Anti-Retroviral Agents / therapeutic use*
  • Benzoxazines / therapeutic use
  • Contraceptive Agents, Female / therapeutic use*
  • Cyclopropanes
  • Drug Interactions*
  • Eswatini
  • Female
  • HIV Infections / drug therapy*
  • Humans
  • Lopinavir / therapeutic use
  • Middle Aged
  • Nevirapine / therapeutic use
  • Pregnancy
  • Pregnancy, Unplanned*
  • Ritonavir / therapeutic use
  • Young Adult

Substances

  • Alkynes
  • Anti-Retroviral Agents
  • Benzoxazines
  • Contraceptive Agents, Female
  • Cyclopropanes
  • Lopinavir
  • Nevirapine
  • efavirenz
  • Ritonavir