Replication-competent retroviruses in gene-modified T cells used in clinical trials: is it time to revise the testing requirements?

Mol Ther. 2012 Feb;20(2):246-9. doi: 10.1038/mt.2011.288.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Clinical Trials as Topic
  • Genetic Therapy / adverse effects*
  • Genetic Vectors / genetics*
  • Humans
  • Retroviridae / genetics*
  • Retroviridae / physiology
  • T-Lymphocytes / metabolism*
  • Toxicity Tests / economics
  • Toxicity Tests / standards
  • Transduction, Genetic
  • Virus Replication / genetics*