Abstract
Vascular catheters coated with a novel antimicrobial agent (MBX1631) were studied for their ability to protect against bacterial colonization in vitro and in a rabbit model. MBX1631-coated catheters were significantly less likely to become colonized than control catheters both in vitro and in vivo (P < 0.001). Furthermore, device-associated infection was significantly lower in MBX1631-coated catheters than in uncoated ones (P < 0.005).
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use*
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Bacteria / drug effects
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Bacteria / growth & development
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Catheter-Related Infections / microbiology*
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Catheter-Related Infections / prevention & control*
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Catheters / microbiology*
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Colony Count, Microbial
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Culture Media
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Indoles / pharmacology*
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Indoles / therapeutic use*
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Rabbits
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Staphylococcal Infections / microbiology
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Staphylococcal Infections / prevention & control
Substances
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Anti-Bacterial Agents
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Culture Media
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Indoles
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MBX1631