In vitro potency and in vivo efficacy of a novel bis-indole antimicrobial compound in reducing catheter colonization

Antimicrob Agents Chemother. 2012 Apr;56(4):2201-4. doi: 10.1128/AAC.05521-11. Epub 2012 Jan 23.

Abstract

Vascular catheters coated with a novel antimicrobial agent (MBX1631) were studied for their ability to protect against bacterial colonization in vitro and in a rabbit model. MBX1631-coated catheters were significantly less likely to become colonized than control catheters both in vitro and in vivo (P < 0.001). Furthermore, device-associated infection was significantly lower in MBX1631-coated catheters than in uncoated ones (P < 0.005).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use*
  • Bacteria / drug effects
  • Bacteria / growth & development
  • Catheter-Related Infections / microbiology*
  • Catheter-Related Infections / prevention & control*
  • Catheters / microbiology*
  • Colony Count, Microbial
  • Culture Media
  • Indoles / pharmacology*
  • Indoles / therapeutic use*
  • Rabbits
  • Staphylococcal Infections / microbiology
  • Staphylococcal Infections / prevention & control

Substances

  • Anti-Bacterial Agents
  • Culture Media
  • Indoles
  • MBX1631