Abstract
Pre-operative chemotherapy for 7 days with 5'-DFUR (p.o.) were carried out in the patients with gastric, breast, thyroid and colon cancers. The concentration of 5-fluorouracil (5-FU) in tumor cells was higher than that in the normal tissue. In case of breast cancer, it was 10 times higher than normal tissue. The concentration of 5-FU at the metastatic lymph nodes in gastric cancer was considerably high. The pattern of DNA histogram changed when chemotherapy was applied, and we observed the G2 and M phase block.
MeSH terms
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / therapeutic use*
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / metabolism
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Breast Neoplasms / surgery
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Cell Cycle / drug effects
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Colonic Neoplasms / drug therapy*
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Colonic Neoplasms / metabolism
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Colonic Neoplasms / surgery
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Combined Modality Therapy
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Female
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Floxuridine / administration & dosage
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Floxuridine / pharmacokinetics
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Floxuridine / therapeutic use*
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Fluorouracil / pharmacokinetics
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Humans
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Lymph Nodes / enzymology
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Lymph Nodes / metabolism
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Pentosyltransferases / metabolism
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Preoperative Care
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Pyrimidine Phosphorylases
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Stomach Neoplasms / drug therapy*
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Stomach Neoplasms / metabolism
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Stomach Neoplasms / surgery
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Thyroid Neoplasms / drug therapy*
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Thyroid Neoplasms / metabolism
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Thyroid Neoplasms / surgery
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Tissue Distribution
Substances
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Antineoplastic Agents
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Floxuridine
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Pentosyltransferases
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Pyrimidine Phosphorylases
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Fluorouracil
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doxifluridine