[A study on pre-operative administration of 5'-DFUR in carcinomas of the gastric, breast, thyroid and colon]

Gan To Kagaku Ryoho. 1990 Dec;17(12):2415-20.
[Article in Japanese]

Abstract

Pre-operative chemotherapy for 7 days with 5'-DFUR (p.o.) were carried out in the patients with gastric, breast, thyroid and colon cancers. The concentration of 5-fluorouracil (5-FU) in tumor cells was higher than that in the normal tissue. In case of breast cancer, it was 10 times higher than normal tissue. The concentration of 5-FU at the metastatic lymph nodes in gastric cancer was considerably high. The pattern of DNA histogram changed when chemotherapy was applied, and we observed the G2 and M phase block.

Publication types

  • English Abstract

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / therapeutic use*
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / surgery
  • Cell Cycle / drug effects
  • Colonic Neoplasms / drug therapy*
  • Colonic Neoplasms / metabolism
  • Colonic Neoplasms / surgery
  • Combined Modality Therapy
  • Female
  • Floxuridine / administration & dosage
  • Floxuridine / pharmacokinetics
  • Floxuridine / therapeutic use*
  • Fluorouracil / pharmacokinetics
  • Humans
  • Lymph Nodes / enzymology
  • Lymph Nodes / metabolism
  • Pentosyltransferases / metabolism
  • Preoperative Care
  • Pyrimidine Phosphorylases
  • Stomach Neoplasms / drug therapy*
  • Stomach Neoplasms / metabolism
  • Stomach Neoplasms / surgery
  • Thyroid Neoplasms / drug therapy*
  • Thyroid Neoplasms / metabolism
  • Thyroid Neoplasms / surgery
  • Tissue Distribution

Substances

  • Antineoplastic Agents
  • Floxuridine
  • Pentosyltransferases
  • Pyrimidine Phosphorylases
  • Fluorouracil
  • doxifluridine