Leukocyte adhesion molecules and myocardial ischemia

C W Smith; D C Anderson; A A Taylor; R D Rossen; M L Entman

doi:10.1016/1050-1738(91)90023-8

Leukocyte adhesion molecules and myocardial ischemia

Trends Cardiovasc Med. 1991 May-Jun;1(4):167-70. doi: 10.1016/1050-1738(91)90023-8.

Authors

C W Smith¹, D C Anderson, A A Taylor, R D Rossen, M L Entman

Affiliation

¹ Speros P. Martel Leukocyte Biology Laboratory, Department of Pediatrics, The Methodist Hospital, Baylor College of Medicine, Houston, TX 77054, USA.

PMID: 21239320
DOI: 10.1016/1050-1738(91)90023-8

Abstract

Current evidence strongly indicates that neutrophils contribute to the injury seen after ischemia and reperfusion of various tissues. Potentially important therapeutic targets are the specific adhesion mechanisms supporting neutrophil extravasation and secretory activity. Several such mechanisms have been characterized recently at a molecular level in vitro, and warrant investigation in relevant models of human disease.