Genetic modification of T cells

Chiara Bonini; Malcolm K Brenner; Helen E Heslop; Richard A Morgan

doi:10.1016/j.bbmt.2010.09.019

Genetic modification of T cells

Biol Blood Marrow Transplant. 2011 Jan;17(1 Suppl):S15-20. doi: 10.1016/j.bbmt.2010.09.019.

Authors

Chiara Bonini¹, Malcolm K Brenner, Helen E Heslop, Richard A Morgan

Affiliation

¹ Experimental Hematology Unit, Research Division of Regenerative Medicine, Gene Therapy and Stem Cells, Hematology and BMT Unit, Department of Oncology, San Raffaele Scientific Institute, Milano, Italy.

Abstract

Adoptively transferred T cells have shown activity in treating viral infections after hemopoietic transplantation and anti-tumor activity against some malignancies such as melanoma and lymphoma. Current research focuses on defining the optimum type of cell for transfer to improve persistence and genetically modifying infused T cells to augment function, overcome tumor evasion strategies and allow ablation should adverse effects occur.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Adoptive Transfer / methods*
Adoptive Transfer / standards
Humans
Immune Evasion
T-Lymphocytes / immunology
T-Lymphocytes / metabolism
T-Lymphocytes / transplantation*
Transfection*
Tumor Escape

Abstract

Publication types

MeSH terms

Grants and funding