Abstract
We performed a retrospective case-cohort study of 50 obese pediatric patients aged 2 to 18 years who received scheduled gentamicin therapy, with serum peak and trough concentrations measured. Obese pediatric patients had significantly higher gentamicin serum peak and trough concentrations despite receiving significantly lower mg/kg of actual body weight doses of gentamicin.
MeSH terms
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Adolescent
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / pharmacokinetics*
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Child
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Child, Preschool
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Cohort Studies
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Female
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Gentamicins / administration & dosage
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Gentamicins / pharmacokinetics*
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Humans
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Male
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Obesity / complications*
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Obesity / metabolism
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Retrospective Studies
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Serum / chemistry*
Substances
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Anti-Bacterial Agents
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Gentamicins