Suicidal attempts and increased right amygdala volume in schizophrenia

Schizophr Res. 2011 Jan;125(1):30-40. doi: 10.1016/j.schres.2010.08.023. Epub 2010 Sep 25.

Abstract

Suicide is a major cause of death in schizophrenia. Neurobiological studies suggest that suicidality is associated with abnormal brain structure and connectivity in fronto-temporo-limbic regions. However, it is still unclear whether suicidality in schizophrenia is related to volumetric abnormalities in subcortical structures that play a key role in emotion regulation, aggression and impulse control. Therefore, we aimed to examine whether the volume of selected subcortical regions is associated with previous suicidal attempts and self-aggression in schizophrenia. For this cross-sectional study, we recruited 50 outpatients with schizophrenia and 50 healthy controls (HC) matched for age and gender. Fourteen patients had a history of one or more suicide attempts. Different forms of aggression were assessed using the Modified Overt Aggression Scale. All participants underwent structural MR imaging at 3 Tesla. Physical volumetric measures were calculated for the lateral ventricles, thalamus, hippocampus, amygdala, caudate, putamen, pallidum and accumbens using an automatic segmentation method on T1-weighted high-resolution (voxel size 1×1×1mm(3)) images. Multivariate and follow-up univariate ANOVAs revealed a selective increase in volume in the right amygdala of patients with a history of suicidality compared both to patients without such a history and HC. Moreover, in the entire patient group increased right amygdala volume was related to increased self-aggression. Our findings suggest that right amygdala hypertrophy may be a risk factor for suicide attempts in patients with schizophrenia and this could be relevant for suicide prevention.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amygdala / pathology*
  • Analysis of Variance
  • Brain Mapping
  • Female
  • Functional Laterality / physiology*
  • Humans
  • Imaging, Three-Dimensional / methods
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Psychiatric Status Rating Scales
  • Schizophrenia / pathology*
  • Schizophrenic Psychology*
  • Statistics as Topic
  • Suicide, Attempted / psychology*
  • Young Adult