Seventy-four-year-old woman with myelodysplastic syndrome and splenomegaly

Alison Motosue; Jack Alperin; Mohamed T Elghetany; Rana Bonds

doi:10.2500/aap.2010.31.3300

Seventy-four-year-old woman with myelodysplastic syndrome and splenomegaly

Allergy Asthma Proc. 2010 May-Jun;31(3):252-7. doi: 10.2500/aap.2010.31.3300.

Authors

Alison Motosue¹, Jack Alperin, Mohamed T Elghetany, Rana Bonds

Affiliation

¹ Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas 77555-1083, USA.

PMID: 20615327
DOI: 10.2500/aap.2010.31.3300

Abstract

We present a 74-year-old woman with a recent diagnosis of myelodysplastic syndrome who presented with left upper quadrant abdominal pain and fatigue with significant splenomegaly, anemia, and thrombocytopenia. She underwent splenectomy and bone marrow biopsy. Pathology of both spleen and bone marrow revealed an unusual diagnosis. A review of the differential diagnosis, laboratory tests, nature of the underlying disease, and treatment are provided.

Publication types

Case Reports

MeSH terms

Abdominal Pain
Aged
Bone Marrow / enzymology*
Bone Marrow / pathology
Diagnosis, Differential
Female
Humans
Mast Cells / pathology
Mastocytosis, Systemic / diagnosis*
Mastocytosis, Systemic / pathology
Mastocytosis, Systemic / physiopathology
Mastocytosis, Systemic / therapy
Myelodysplastic Syndromes / diagnosis*
Myelodysplastic Syndromes / pathology
Myelodysplastic Syndromes / physiopathology
Myelodysplastic Syndromes / therapy
Spleen / pathology
Splenomegaly
Thrombocytopenia
Tryptases / metabolism

Substances

Tryptases