Impact of arginase II on CBF in experimental cortical impact injury in mice using MRI

J Cereb Blood Flow Metab. 2010 Jun;30(6):1105-9. doi: 10.1038/jcbfm.2010.47. Epub 2010 Apr 7.

Abstract

Traumatic brain injury (TBI) results in reduced cerebral blood flow (CBF) and low levels of the vasodilator nitric oxide (NO) may be involved. Arginase II negatively regulates NO production through competition for the substrate L-arginine. We determined whether arginase II-deficient (ArgII(-/-)) mice would show improved CBF after TBI through arterial spin-labeling magnetic resonance imaging (MRI). The ArgII(-/-) mice exhibit a significantly improved CBF recovery after trauma in the perilesional brain (P=0.0015) and in various other brain regions. In conclusion, arginase II deficiency leads to a better CBF recovery after TBI and implicates arginase II in hemodynamic processes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arginase*
  • Blood Flow Velocity*
  • Brain Injuries / diagnostic imaging
  • Brain Injuries / enzymology*
  • Brain Injuries / genetics
  • Brain Injuries / pathology
  • Brain Injuries / physiopathology*
  • Cerebral Cortex / blood supply*
  • Cerebral Cortex / pathology
  • Cerebrovascular Circulation*
  • Magnetic Resonance Angiography*
  • Male
  • Mice
  • Mice, Knockout
  • Radiography

Substances

  • Arg2 protein, mouse
  • Arginase