Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy

Nano Lett. 2008 May;8(5):1492-500. doi: 10.1021/nl080496z. Epub 2008 Apr 16.

Abstract

We report noninvasive modulation of in vivo tumor radiation response using gold nanoshells. Mild-temperature hyperthermia generated by near-infrared illumination of gold nanoshell-laden tumors, noninvasively quantified by magnetic resonance temperature imaging, causes an early increase in tumor perfusion that reduces the hypoxic fraction of tumors. A subsequent radiation dose induces vascular disruption with extensive tumor necrosis. Gold nanoshells sequestered in the perivascular space mediate these two tumor vasculature-focused effects to improve radiation response of tumors. This novel integrated antihypoxic and localized vascular disrupting therapy can potentially be combined with other conventional antitumor therapies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Colorectal Neoplasms / pathology*
  • Colorectal Neoplasms / therapy*
  • Gold / therapeutic use*
  • Humans
  • Hyperthermia, Induced / methods*
  • Light
  • Male
  • Mice
  • Mice, Nude
  • Nanomedicine / methods
  • Nanostructures / therapeutic use*
  • Neovascularization, Pathologic / pathology*
  • Neovascularization, Pathologic / therapy*
  • Radiation Dosage
  • Treatment Outcome

Substances

  • Gold