Anastomotic pseudoaneurysm is a known complication following carotid artery endarterectomy and aortobifemoral bypass surgeries. However, giant concurrent carotid and femoral artery anastomotic pseudoaneurysms are rare. We herein report a case of successful treatment of multiple giant anastomotic pseudoaneurysms using a combined endovascular and surgical approach. Our case highlights the fact that endovascular techniques can facilitate open surgical repair of complex anastomotic pseudoaneurysms.