Worldwide variation in the relative importance of hepatitis B and hepatitis C viruses in hepatocellular carcinoma: a systematic review

S A Raza; G M Clifford; S Franceschi

doi:10.1038/sj.bjc.6603649

Worldwide variation in the relative importance of hepatitis B and hepatitis C viruses in hepatocellular carcinoma: a systematic review

Br J Cancer. 2007 Apr 10;96(7):1127-34. doi: 10.1038/sj.bjc.6603649.

Authors

S A Raza¹, G M Clifford, S Franceschi

Affiliation

¹ Department of Surgery, The Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan.

Abstract

We combined information published worldwide on the seroprevalence of hepatitis B surface antigen (HbsAg) and antibodies against hepatitis C virus (anti-HCV) in 27 881 hepatocellular carcinomas (HCCs) from 90 studies. A predominance of HBsAg was found in HCCs from most Asian, African and Latin American countries, but anti-HCV predominated in Japan, Pakistan, Mongolia and Egypt. Anti-HCV was found more often than HBsAg in Europe and the United States.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

MeSH terms

Carcinoma, Hepatocellular / epidemiology
Carcinoma, Hepatocellular / immunology
Carcinoma, Hepatocellular / virology*
Global Health
Hepacivirus / immunology*
Hepatitis B / epidemiology
Hepatitis B / immunology*
Hepatitis B Surface Antigens / blood
Hepatitis B virus / immunology*
Hepatitis C / epidemiology
Hepatitis C / immunology*
Hepatitis C Antibodies / blood
Humans
Liver Neoplasms / epidemiology
Liver Neoplasms / immunology
Liver Neoplasms / virology*
Seroepidemiologic Studies

Substances

Hepatitis B Surface Antigens
Hepatitis C Antibodies