Abstract
Sixty rifampin (RIF)-resistant and 75 RIF-susceptible Mycobacterium tuberculosis isolates from Shandong Province, China, were analyzed for rpoB gene mutations and genotyped. Mycobacterial interspersed repetitive unit (MIRU) genotype 223325173533 was overrepresented among RIF-resistant isolates. MIRU combined with IS6110 restriction fragment length polymorphism analysis as the second-line genotyping method may reflect epidemiologic links more reliably than each method alone.
MeSH terms
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Antibiotics, Antitubercular / pharmacology*
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Bacterial Proteins / genetics*
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Bacterial Typing Techniques
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China
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DNA Transposable Elements
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DNA-Directed RNA Polymerases
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Drug Resistance, Bacterial / genetics*
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Genotype
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Humans
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Interspersed Repetitive Sequences / genetics
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Microbial Sensitivity Tests
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Mutation*
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Mycobacterium tuberculosis / classification*
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Mycobacterium tuberculosis / drug effects
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Mycobacterium tuberculosis / genetics
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Mycobacterium tuberculosis / isolation & purification
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Polymorphism, Restriction Fragment Length
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Rifampin / pharmacology*
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Sentinel Surveillance
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Tuberculosis, Pulmonary / microbiology
Substances
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Antibiotics, Antitubercular
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Bacterial Proteins
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DNA Transposable Elements
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rpoB protein, Mycobacterium tuberculosis
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DNA-Directed RNA Polymerases
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Rifampin