rpoB Gene mutations and molecular characterization of rifampin-resistant Mycobacterium tuberculosis isolates from Shandong Province, China

J Clin Microbiol. 2006 Sep;44(9):3409-12. doi: 10.1128/JCM.00515-06.

Abstract

Sixty rifampin (RIF)-resistant and 75 RIF-susceptible Mycobacterium tuberculosis isolates from Shandong Province, China, were analyzed for rpoB gene mutations and genotyped. Mycobacterial interspersed repetitive unit (MIRU) genotype 223325173533 was overrepresented among RIF-resistant isolates. MIRU combined with IS6110 restriction fragment length polymorphism analysis as the second-line genotyping method may reflect epidemiologic links more reliably than each method alone.

Publication types

  • Evaluation Study

MeSH terms

  • Antibiotics, Antitubercular / pharmacology*
  • Bacterial Proteins / genetics*
  • Bacterial Typing Techniques
  • China
  • DNA Transposable Elements
  • DNA-Directed RNA Polymerases
  • Drug Resistance, Bacterial / genetics*
  • Genotype
  • Humans
  • Interspersed Repetitive Sequences / genetics
  • Microbial Sensitivity Tests
  • Mutation*
  • Mycobacterium tuberculosis / classification*
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / genetics
  • Mycobacterium tuberculosis / isolation & purification
  • Polymorphism, Restriction Fragment Length
  • Rifampin / pharmacology*
  • Sentinel Surveillance
  • Tuberculosis, Pulmonary / microbiology

Substances

  • Antibiotics, Antitubercular
  • Bacterial Proteins
  • DNA Transposable Elements
  • rpoB protein, Mycobacterium tuberculosis
  • DNA-Directed RNA Polymerases
  • Rifampin