Abstract
Oxidative stress and inflammation play a crucial role in atherosclerosis. However, prospective clinical trials of dietary antioxidants with anti-inflammatory properties, such as alpha-tocopherol (AT), have not yielded positive results. AT supplementation decreases gamma-tocopherol (GT) levels. GT is an antioxidant with potent anti-inflammatory activity, and plasma GT levels are inversely associated with cardiovascular diseases. Thus, studies using pure GT, alone or in conjunction with AT, will elucidate its utility in cardiovascular disease prevention.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Antioxidants / pharmacokinetics*
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Antioxidants / therapeutic use
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Arteriosclerosis / metabolism
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Arteriosclerosis / prevention & control
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Biological Availability
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Cardiovascular Diseases / metabolism
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Cardiovascular Diseases / prevention & control*
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Humans
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Intestinal Absorption
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Oxidative Stress
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alpha-Tocopherol / pharmacokinetics*
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alpha-Tocopherol / therapeutic use
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gamma-Tocopherol / pharmacokinetics*
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gamma-Tocopherol / therapeutic use
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Antioxidants
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gamma-Tocopherol
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alpha-Tocopherol