Abstract
Lactadherin is a phosphatidylserine-binding glycoprotein secreted by macrophages. Less than 0.5% of normal circulating red cells showed any binding to lactadherin. However, the red cells from patients with sickle cell disease showed 2 to 10-fold increases in lactadherin binding. Further, lactadherin stimulated the phagocytosis of sickle red blood cells by macrophages suggesting a potential role in sickle red cell clearance.
Publication types
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Comparative Study
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Letter
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adult
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Anemia, Sickle Cell / blood*
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Antigens, Surface / blood*
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Erythrocytes, Abnormal / metabolism*
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Humans
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Macrophages / physiology*
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Middle Aged
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Milk Proteins / blood*
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Phagocytosis / physiology*
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Phosphatidylserines / biosynthesis*
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Phosphatidylserines / blood*
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Phosphatidylserines / genetics
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Protein Binding
Substances
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Antigens, Surface
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MFGE8 protein, human
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Milk Proteins
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Phosphatidylserines