Abstract
A case of beta-lactam antibiotic-induced pseudoporphyria is presented. A 24-year-old African American woman with systemic lupus erythematosus and end-stage renal disease on hemodialysis developed tense bullae on her forehead and cheeks after exposure to ampicillin-sulbactam and cefepime. Histologically, the lesions were similar to porphyria cutanea tarda, but without the associated porphyrin abnormalities. The lesions resolved spontaneously on cessation of the antibiotics.
MeSH terms
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Abdominal Abscess / complications
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Abdominal Abscess / drug therapy
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Ampicillin / adverse effects*
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Anemia, Hemolytic, Autoimmune / complications
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Anti-Bacterial Agents / adverse effects
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Biopsy
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Fallopian Tube Diseases / complications
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Fallopian Tube Diseases / drug therapy
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Female
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Forehead
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Humans
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Kidney Failure, Chronic / complications
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Kidney Failure, Chronic / therapy
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Leukocyte Count
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Lupus Erythematosus, Systemic / complications
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Middle Aged
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Ovarian Diseases / complications
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Ovarian Diseases / drug therapy
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Pruritus / chemically induced
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Renal Dialysis
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Sickle Cell Trait / complications
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Skin / pathology
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Skin Diseases, Vesiculobullous / chemically induced*
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Skin Diseases, Vesiculobullous / pathology
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Sulbactam / adverse effects*
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Thrombocytopenia / complications
Substances
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Anti-Bacterial Agents
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sultamicillin
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Ampicillin
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Sulbactam