Abstract
One-third of the cases of invasive group B streptococcal (GBS) disease now occur in adults >or=65 years old. Serotype V is most frequent among these invasive isolates. The safety and immunogenicity of type V GBS capsular polysaccharide (CPS)-tetanus toxoid (V-TT) conjugate vaccine (CV) were assessed in 32 healthy adults 65-85 years old who were randomized to receive a single intramuscular dose of V-TT CV (n=22) or licensed tetanus-diphtheria toxoid vaccine (Td) (n=10; double-masked design). V-TT CV elicited significant increases in type V CPS-specific immunoglobulin (Ig) G, IgM, and IgA serum concentrations 4, 8, 26, and 52 weeks after immunization. V-TT-induced type V CPS-specific antibodies promoted the opsonophagocytic killing of type V GBS in vitro. Both vaccines elicited similar concentrations of TT-specific IgG in 4-week postimmunization serum samples. These results suggest the potential for prevention of invasive type V GBS infections in healthy elderly adults through immunization.
Publication types
-
Clinical Trial
-
Clinical Trial, Phase I
-
Comparative Study
-
Randomized Controlled Trial
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Aged
-
Aged, 80 and over
-
Antibodies, Bacterial / blood*
-
Antibody Specificity
-
Diphtheria-Tetanus Vaccine / administration & dosage
-
Diphtheria-Tetanus Vaccine / adverse effects
-
Diphtheria-Tetanus Vaccine / immunology
-
Double-Blind Method
-
Female
-
Humans
-
Immunoglobulins / blood
-
Male
-
Polysaccharides, Bacterial / administration & dosage
-
Polysaccharides, Bacterial / adverse effects
-
Polysaccharides, Bacterial / immunology
-
Serotyping
-
Streptococcal Infections / prevention & control
-
Streptococcal Vaccines / administration & dosage
-
Streptococcal Vaccines / adverse effects*
-
Streptococcal Vaccines / immunology*
-
Streptococcus agalactiae / classification
-
Streptococcus agalactiae / immunology*
-
Tetanus Toxoid / administration & dosage
-
Tetanus Toxoid / adverse effects
-
Tetanus Toxoid / immunology
-
Vaccines, Conjugate / administration & dosage
-
Vaccines, Conjugate / adverse effects*
-
Vaccines, Conjugate / immunology*
-
Vaccines, Synthetic / administration & dosage
-
Vaccines, Synthetic / adverse effects
-
Vaccines, Synthetic / immunology
Substances
-
Antibodies, Bacterial
-
Diphtheria-Tetanus Vaccine
-
Immunoglobulins
-
Polysaccharides, Bacterial
-
Streptococcal Vaccines
-
Tetanus Toxoid
-
Vaccines, Conjugate
-
Vaccines, Synthetic