Use of type V group B streptococcal conjugate vaccine in adults 65-85 years old

J Infect Dis. 2004 Aug 1;190(3):558-64. doi: 10.1086/422010. Epub 2004 Jun 30.

Abstract

One-third of the cases of invasive group B streptococcal (GBS) disease now occur in adults >or=65 years old. Serotype V is most frequent among these invasive isolates. The safety and immunogenicity of type V GBS capsular polysaccharide (CPS)-tetanus toxoid (V-TT) conjugate vaccine (CV) were assessed in 32 healthy adults 65-85 years old who were randomized to receive a single intramuscular dose of V-TT CV (n=22) or licensed tetanus-diphtheria toxoid vaccine (Td) (n=10; double-masked design). V-TT CV elicited significant increases in type V CPS-specific immunoglobulin (Ig) G, IgM, and IgA serum concentrations 4, 8, 26, and 52 weeks after immunization. V-TT-induced type V CPS-specific antibodies promoted the opsonophagocytic killing of type V GBS in vitro. Both vaccines elicited similar concentrations of TT-specific IgG in 4-week postimmunization serum samples. These results suggest the potential for prevention of invasive type V GBS infections in healthy elderly adults through immunization.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase I
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antibodies, Bacterial / blood*
  • Antibody Specificity
  • Diphtheria-Tetanus Vaccine / administration & dosage
  • Diphtheria-Tetanus Vaccine / adverse effects
  • Diphtheria-Tetanus Vaccine / immunology
  • Double-Blind Method
  • Female
  • Humans
  • Immunoglobulins / blood
  • Male
  • Polysaccharides, Bacterial / administration & dosage
  • Polysaccharides, Bacterial / adverse effects
  • Polysaccharides, Bacterial / immunology
  • Serotyping
  • Streptococcal Infections / prevention & control
  • Streptococcal Vaccines / administration & dosage
  • Streptococcal Vaccines / adverse effects*
  • Streptococcal Vaccines / immunology*
  • Streptococcus agalactiae / classification
  • Streptococcus agalactiae / immunology*
  • Tetanus Toxoid / administration & dosage
  • Tetanus Toxoid / adverse effects
  • Tetanus Toxoid / immunology
  • Vaccines, Conjugate / administration & dosage
  • Vaccines, Conjugate / adverse effects*
  • Vaccines, Conjugate / immunology*
  • Vaccines, Synthetic / administration & dosage
  • Vaccines, Synthetic / adverse effects
  • Vaccines, Synthetic / immunology

Substances

  • Antibodies, Bacterial
  • Diphtheria-Tetanus Vaccine
  • Immunoglobulins
  • Polysaccharides, Bacterial
  • Streptococcal Vaccines
  • Tetanus Toxoid
  • Vaccines, Conjugate
  • Vaccines, Synthetic