Case report: severe symptomatic hyponatremia associated with lisinopril therapy

Am J Med Sci. 1992 Mar;303(3):177-9. doi: 10.1097/00000441-199203000-00009.

Abstract

A 63-year-old white female who was being treated for hypertension with lisinopril presented with seizures, altered mental status, and a serum sodium of 101 mEq/L. Serum sodium prior to initiation of lisinopril therapy was 137 mEq/L. The hyponatremia was corrected and did not recur after lisinopril was stopped. The hyponatremia may have been a result of polydipsia and inappropriate antidiuresis secondary to ACE-inhibitor therapy.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Angiotensin-Converting Enzyme Inhibitors / adverse effects*
  • Antihypertensive Agents / adverse effects*
  • Enalapril / adverse effects
  • Enalapril / analogs & derivatives*
  • Enalapril / therapeutic use
  • Female
  • Humans
  • Hypertension / drug therapy*
  • Hyponatremia / chemically induced*
  • Hyponatremia / physiopathology
  • Hyponatremia / therapy
  • Lisinopril
  • Mental Disorders / etiology*
  • Middle Aged
  • Seizures / etiology*
  • Sodium / blood

Substances

  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive Agents
  • Enalapril
  • Sodium
  • Lisinopril