Abstract
Administration of amiodarone (AD) to rats leads to marked damage to liver, as evidenced by pathological changes and significant increases in activities of serum marker enzymes and levels of lipids like cholesterol and phospholipids with no alteration in the triglyceride levels. The risk factor, that is the total cholesterol/HDL cholesterol ratio, exhibited increase in the experimental animals, indicating that amiodarone treatment may lead to the development of coronary heart disease.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alanine Transaminase / metabolism
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Alkaline Phosphatase / metabolism
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Amiodarone / pharmacology*
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Animals
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Aspartate Aminotransferases / metabolism
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Cholesterol / blood
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Isoenzymes / metabolism
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L-Lactate Dehydrogenase / metabolism
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Lipid Metabolism*
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Lipids / blood
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Liver / drug effects
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Liver / metabolism*
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Liver / pathology
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Male
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Phospholipids / metabolism
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Rats
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Rats, Wistar
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Triglycerides / metabolism
Substances
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Isoenzymes
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Lipids
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Phospholipids
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Triglycerides
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Cholesterol
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L-Lactate Dehydrogenase
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Aspartate Aminotransferases
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Alanine Transaminase
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Alkaline Phosphatase
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Amiodarone