Numb: "Adapting" notch for endocytosis

Dev Cell. 2002 Aug;3(2):155-6. doi: 10.1016/s1534-5807(02)00228-9.

Abstract

During sensory organ precursor divisions in Drosophila, the numb gene product segregates asymmetrically into one of the two daughter cells, to which it confers a specific fate by inhibiting Notch signaling. In this issue of Developmental Cell, Berdnik et al. show that Numb recruits alpha-Adaptin and that this physical interaction plays a role in downregulating Notch, presumably by stimulating endocytosis of Notch.

Publication types

  • Review
  • Comment

MeSH terms

  • Adaptor Protein Complex alpha Subunits
  • Animals
  • Body Patterning / physiology*
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Cell Differentiation / physiology*
  • Cell Lineage / physiology*
  • Drosophila Proteins
  • Drosophila melanogaster / cytology
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / metabolism
  • Endocytosis / physiology*
  • Juvenile Hormones / genetics
  • Juvenile Hormones / metabolism*
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Receptors, Notch
  • Sense Organs / cytology
  • Sense Organs / embryology
  • Sense Organs / metabolism
  • Stem Cells / cytology
  • Stem Cells / metabolism*

Substances

  • Adaptor Protein Complex alpha Subunits
  • Carrier Proteins
  • Drosophila Proteins
  • Juvenile Hormones
  • Membrane Proteins
  • N protein, Drosophila
  • Receptors, Notch
  • numb protein, Drosophila