The natural resistance-associated macrophage protein 1 Slc11a1 (formerly Nramp1) and iron metabolism in macrophages

Microbes Infect. 2002 Mar;4(3):351-9. doi: 10.1016/s1286-4579(02)01548-4.

Abstract

Slc11a1 (solute carrier family 11 member 1) (formerly Nramp1) modulation of iron metabolism in macrophages plays an important role in early phase macrophage activation, and therefore host innate immunity. This review focuses on the role of Nramp1 in intramacrophage iron metabolism, with emphasis on the two prevailing mechanisms of Nramp1 modulation of iron metabolism in macrophages.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacterial Infections / immunology
  • Bacterial Infections / metabolism*
  • Base Sequence
  • Cation Transport Proteins / metabolism*
  • Cytokines / physiology
  • Immunity, Innate
  • Iron / metabolism*
  • Macrophages / immunology
  • Macrophages / metabolism*
  • Mice
  • Models, Biological
  • Molecular Sequence Data
  • Promoter Regions, Genetic

Substances

  • Cation Transport Proteins
  • Cytokines
  • natural resistance-associated macrophage protein 1
  • Iron