Modulation of monocyte-macrophage function with alpha-tocopherol: implications for atherosclerosis

Nutr Rev. 2002 Jan;60(1):8-14. doi: 10.1301/002966402760240381.

Abstract

Cardiovascular disease is the leading cause of morbidity and mortality in the Western world. Monocyte-macrophages are crucial cells in atherogenesis. Several lines of evidence suggest that antioxidants, especially alpha-tocopherol, have beneficial effects with regard to cardiovascular disease. Alpha-tocopherol has beneficial effects on cell functions that are pivotal in atherogenesis. Alpha-tocopherol inhibits platelet aggregation and proinflammatory activity of monocytes. In vitro data also support an effect of alpha-tocopherol on smooth muscle cell proliferation and endothelial function. Finally, recent data support an effect of alpha-tocopherol on macrophage function. The mounting evidence from in vitro and in vivo studies provides a sound scientific basis for alpha-tocopherol supplementation. Further clinical trials are required, however, before a definitive recommendation can be made for primary and secondary prevention of heart disease.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antioxidants / pharmacology*
  • Arteriosclerosis / etiology*
  • Arteriosclerosis / metabolism
  • Arteriosclerosis / prevention & control
  • Blood Platelets / metabolism
  • Humans
  • Macrophages / drug effects*
  • Macrophages / metabolism
  • Macrophages / physiology
  • Monocytes / drug effects*
  • Monocytes / metabolism
  • Monocytes / physiology
  • Platelet Aggregation Inhibitors / pharmacology
  • alpha-Tocopherol / pharmacology*

Substances

  • Antioxidants
  • Platelet Aggregation Inhibitors
  • alpha-Tocopherol