Abstract
Prosthetic heart valve sewing cuffs coated with minocycline and rifampin exhibited in vitro zones of inhibition against all 52 tested clinical isolates responsible for prosthetic valve endocarditis. An in vitro elution study of these coated sewing cuffs demonstrated residual zones of inhibition against Staphylococcus epidermidis for at least 4 weeks.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Antibiotics, Antitubercular / pharmacology*
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Antibiotics, Antitubercular / therapeutic use
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Bacillus / drug effects
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Drug Therapy, Combination
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Heart Valve Prosthesis / microbiology*
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Humans
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Microbial Sensitivity Tests
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Minocycline / pharmacology*
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Minocycline / therapeutic use
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Prosthesis-Related Infections / prevention & control
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Rifampin / pharmacology*
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Rifampin / therapeutic use
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Staphylococcus epidermidis / drug effects*
Substances
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Anti-Bacterial Agents
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Antibiotics, Antitubercular
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Minocycline
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Rifampin