Effect of eugenol and tincture of crataegus (TCR) on in vitro oxidation of LDL + VLDL isolated from plasma of non-insulin dependent diabetic patients

K Rajalakshmi; P Gurumurthi; S N Devaraj

Effect of eugenol and tincture of crataegus (TCR) on in vitro oxidation of LDL + VLDL isolated from plasma of non-insulin dependent diabetic patients

Indian J Exp Biol. 2000 May;38(5):509-11.

Authors

K Rajalakshmi¹, P Gurumurthi, S N Devaraj

Affiliation

¹ Department of Biochemistry and Molecular Biology, University of Madras Guindy Campus, Chennai 600 025, India.

PMID: 11272419

Abstract

The present study was carried out to study the effect of antioxidants on oxidised LDL + VLDL and found that vitamin E, eugenol and tincture of crataegus (antioxidants) inhibited oxidation of (LDL + VLDL) similar to standard antioxidant (butylated hydroxy toluene). Vitamin C acted as an antioxidant at lower concentration, and prooxidant at higher concentration.

MeSH terms

Antioxidants / pharmacology
Crataegus
Diabetes Mellitus, Type 2 / blood*
Eugenol / pharmacology*
Humans
In Vitro Techniques
Lipoproteins, LDL / blood
Lipoproteins, VLDL / blood
Oxidation-Reduction
Plant Extracts / pharmacology*
Thiobarbituric Acid Reactive Substances / metabolism

Substances

Antioxidants
Lipoproteins, LDL
Lipoproteins, VLDL
Plant Extracts
Thiobarbituric Acid Reactive Substances
Eugenol
crataegus extract