Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness

Liang Han; Nathachit Limjunyawong; Fei Ru; Zhe Li; Olivia J Hall; Haley Steele; Yuyan Zhu; Julie Wilson; Wayne Mitzner; Marian Kollarik; Bradley J Undem; Brendan J Canning; Xinzhong Dong

doi:10.1038/s41593-018-0074-8

Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness

Nat Neurosci. 2018 Mar;21(3):324-328. doi: 10.1038/s41593-018-0074-8. Epub 2018 Feb 5.

Authors

Liang Han^{1

2}, Nathachit Limjunyawong³, Fei Ru⁴, Zhe Li³, Olivia J Hall⁵, Haley Steele⁶, Yuyan Zhu⁶, Julie Wilson⁶, Wayne Mitzner⁷, Marian Kollarik⁴, Bradley J Undem⁴, Brendan J Canning⁴, Xinzhong Dong^{8

9}

Affiliations

¹ The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. liang.han@biology.gatech.edu.
² School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA. liang.han@biology.gatech.edu.
³ The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
⁴ Department of Medicine, Division of Allergy and Clinical Immunology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
⁵ W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
⁶ School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
⁷ Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
⁸ The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. xdong2@jhmi.edu.
⁹ Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD, USA. xdong2@jhmi.edu.

Abstract

Asthma, accompanied by lung inflammation, bronchoconstriction and airway hyper-responsiveness, is a significant public health burden. Here we report that Mas-related G protein-coupled receptors (Mrgprs) are expressed in a subset of vagal sensory neurons innervating the airway and mediates cholinergic bronchoconstriction and airway hyper-responsiveness. These findings provide insights into the neural mechanisms underlying the pathogenesis of asthma.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Anaphylaxis / physiopathology
Animals
Asthma / genetics*
Asthma / physiopathology*
Bronchoconstriction*
Calcium Signaling
Guinea Pigs
Humans
Mice
Mice, Inbred C57BL
Mice, Knockout
Parasympathetic Nervous System / physiopathology
Plethysmography
Receptors, G-Protein-Coupled / genetics*
Respiratory Hypersensitivity / genetics*
Respiratory Hypersensitivity / physiopathology*
Respiratory Mechanics
Sensory Receptor Cells*
Vagus Nerve / physiopathology*

Substances

Receptors, G-Protein-Coupled

Abstract

Publication types

MeSH terms

Substances

Grants and funding