A viscoelastic adhesive epicardial patch for treating myocardial infarction

Xiao Lin; Yue Liu; Aobing Bai; Huanhuan Cai; Yanjie Bai; Wei Jiang; Huilin Yang; Xinhong Wang; Lei Yang; Ning Sun; Huajian Gao

doi:10.1038/s41551-019-0380-9

A viscoelastic adhesive epicardial patch for treating myocardial infarction

Nat Biomed Eng. 2019 Aug;3(8):632-643. doi: 10.1038/s41551-019-0380-9. Epub 2019 Apr 15.

Authors

Xiao Lin¹, Yue Liu², Aobing Bai³, Huanhuan Cai³, Yanjie Bai⁴, Wei Jiang³, Huilin Yang^{1

5}, Xinhong Wang³, Lei Yang^{6

7

8}, Ning Sun^{9

10

11}, Huajian Gao¹²

Affiliations

¹ Orthopedic Institute, Department of Orthopedics, The First Affiliated Hospital, Soochow University, Suzhou, China.
² School of Engineering, Brown University, Providence, RI, USA.
³ Department of Physiology and Pathophysiology, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
⁴ School of Public Health, College of Medicine, Soochow University, Suzhou, China.
⁵ International Research Center for Translational Orthopaedics (IRCTO), Suzhou, China.
⁶ Orthopedic Institute, Department of Orthopedics, The First Affiliated Hospital, Soochow University, Suzhou, China. ylei@hebut.edu.cn.
⁷ International Research Center for Translational Orthopaedics (IRCTO), Suzhou, China. ylei@hebut.edu.cn.
⁸ School of Materials Science and Engineering, Hebei University of Technology, Tianjin, China. ylei@hebut.edu.cn.
⁹ Department of Physiology and Pathophysiology, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences, Fudan University, Shanghai, China. sunning@fudan.edu.cn.
¹⁰ Institute of Integrative Medicine, Fudan University, Shanghai, China. sunning@fudan.edu.cn.
¹¹ Shanghai Key Laboratory of Clinical Geriatric Medicine, Fudan University, Shanghai, China. sunning@fudan.edu.cn.
¹² School of Engineering, Brown University, Providence, RI, USA. huajian_gao@brown.edu.

PMID: 30988471
DOI: 10.1038/s41551-019-0380-9

Abstract

Acellular epicardial patches that treat myocardial infarction by increasing the mechanical integrity of damaged left ventricular tissues exhibit widely scattered therapeutic efficacy. Here, we introduce a viscoelastic adhesive patch, made of an ionically crosslinked transparent hydrogel, that accommodates the cyclic deformation of the myocardium and outperforms most existing acellular epicardial patches in reversing left ventricular remodelling and restoring heart function after both acute and subacute myocardial infarction in rats. The superior performance of the patch results from its relatively low dynamic modulus, designed at the so-called 'gel point' via finite-element simulations of left ventricular remodelling so as to balance the fluid and solid properties of the material.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biocompatible Materials
Finite Element Analysis
Heart Ventricles / surgery*
Hydrogels
Male
Mice
Models, Animal
Myocardial Infarction / surgery*
Myocardium
Rats
Rats, Sprague-Dawley
Tissue Adhesives / therapeutic use*
Ventricular Remodeling* / physiology

Substances

Biocompatible Materials
Hydrogels
Tissue Adhesives