Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging

James A Winkelmann; Aya Eid; Graham Spicer; Luay M Almassalha; The-Quyen Nguyen; Vadim Backman

doi:10.1038/s41377-018-0117-7

Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging

Light Sci Appl. 2019 Jan 16:8:7. doi: 10.1038/s41377-018-0117-7. eCollection 2019.

Authors

James A Winkelmann¹, Aya Eid¹, Graham Spicer², Luay M Almassalha¹, The-Quyen Nguyen¹, Vadim Backman¹

Affiliations

¹ 1Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 USA.
² 2Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208 USA.

Abstract

Optical coherence tomography angiography relies on motion for contrast and requires at least two data acquisitions per pointwise scanning location. We present a method termed spectral contrast optical coherence tomography angiography using visible light that relies on the spectral signatures of blood for angiography from a single scan using endogenous contrast. We demonstrate the molecular sensitivity of this method, which enables lymphatic vessel, blood, and tissue discrimination.

Abstract

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