Combined Antioxidant and Glucocorticoid Therapy for Safer Treatment of Preterm Birth

Tessa A C Garrud; Dino A Giussani

doi:10.1016/j.tem.2019.02.003

Combined Antioxidant and Glucocorticoid Therapy for Safer Treatment of Preterm Birth

Trends Endocrinol Metab. 2019 Apr;30(4):258-269. doi: 10.1016/j.tem.2019.02.003. Epub 2019 Mar 5.

Authors

Tessa A C Garrud¹, Dino A Giussani²

Affiliations

¹ Department of Physiology Development & Neuroscience, University of Cambridge, Cambridge, UK; Cambridge Cardiovascular Strategic Research Initiative, University of Cambridge, Cambridge, UK; Cambridge Strategic Research Initiative on Reproduction, University of Cambridge, Cambridge, UK.
² Department of Physiology Development & Neuroscience, University of Cambridge, Cambridge, UK; Cambridge Cardiovascular Strategic Research Initiative, University of Cambridge, Cambridge, UK; Cambridge Strategic Research Initiative on Reproduction, University of Cambridge, Cambridge, UK. Electronic address: dag26@cam.ac.uk.

PMID: 30850263
DOI: 10.1016/j.tem.2019.02.003

Abstract

Ante- and postnatal glucocorticoid therapy reduces morbidity and mortality in the preterm infant, and it is therefore one of the best examples of the successful translation of basic experimental science into human clinical practice. However, accruing evidence derived from human clinical studies and from experimental studies in animal models raise serious concerns about potential long-term adverse effects of treatment on growth and neurological and cardiovascular function in the offspring. This review explores whether combined antioxidant and glucocorticoid therapy may be safer than glucocorticoid therapy alone for the treatment of preterm birth.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antioxidants / administration & dosage
Antioxidants / pharmacology*
Drug-Related Side Effects and Adverse Reactions / prevention & control*
Female
Glucocorticoids / administration & dosage
Glucocorticoids / adverse effects*
Humans
Infant, Premature, Diseases / drug therapy*
Oxidative Stress / drug effects*
Pregnancy
Premature Birth / drug therapy*

Substances

Antioxidants
Glucocorticoids

Abstract

Publication types

MeSH terms

Substances

Grants and funding