Restricted fluid resuscitation in suspected sepsis associated hypotension (REFRESH): a pilot randomised controlled trial

Intensive Care Med. 2018 Dec;44(12):2070-2078. doi: 10.1007/s00134-018-5433-0. Epub 2018 Oct 31.

Abstract

Purpose: To determine if a regimen of restricted fluids and early vasopressor compared to usual care is feasible for initial resuscitation of hypotension due to suspected sepsis.

Methods: A prospective, randomised, open-label, clinical trial of a restricted fluid resuscitation regimen in the first 6 h among patients in the emergency department (ED) with suspected sepsis and a systolic blood pressure under 100 mmHg, after minimum 1000 ml of IV fluid. Primary outcome was total fluid administered within 6 h post randomisation.

Results: There were 99 participants (50 restricted volume and 49 usual care) in the intention-to-treat analysis. Median volume from presentation to 6 h in the restricted volume group was 2387 ml [first to third quartile (Q1-Q3) 1750-2750 ml]; 30 ml/kg (Q1-Q3 32-39 ml/kg) vs. 3000 ml (Q1-Q3 2250-3900 ml); 43 ml/kg (Q1-Q3 35-50 ml/kg) in the usual care group (p < 0.001). Median duration of vasopressor support was 21 h (Q1-Q3 9-42 h) vs. 33 h (Q1-Q3 15-50 h), (p = 0.13) in the restricted volume and usual care groups, respectively. At 90-days, 4 of 48 (8%) in the restricted volume group and 3 of 47 (6%) in the usual care group had died. Protocol deviations occurred in 6/50 (12%) in restricted group and 11/49 (22%) in the usual care group, and serious adverse events in four cases (8%) in each group.

Conclusions: A regimen of restricted fluids and early vasopressor in ED patients with suspected sepsis and hypotension appears feasible. Illness severity was moderate and mortality rates low. A future trial is necessary with recruitment of high-risk patients to determine effects on clinical outcomes in this setting.

Keywords: Critical care; Emergency medicine; Fluid therapy; Resuscitation; Sepsis; Septic shock.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Blood Pressure
  • Drug Administration Schedule
  • Emergency Service, Hospital*
  • Feasibility Studies
  • Female
  • Fluid Therapy / methods*
  • Humans
  • Hypotension / etiology
  • Hypotension / therapy*
  • Male
  • Middle Aged
  • Pilot Projects
  • Prospective Studies
  • Resuscitation / methods*
  • Sepsis / complications*
  • Sepsis / therapy
  • Vasoconstrictor Agents / therapeutic use*

Substances

  • Vasoconstrictor Agents